Histidine was first isolated in 1896 from various proteins. It is an essential amino acid for humans.
Histamine is the product of the alpha-decarboxylation of the proteinogenic amino acid histidine.
Histamine plays several important roles in human metabolism, among them serving as the signaling compound for the allergic response.
As a signaling compound, it is normally present in the human body, but its location and concentration are carefully regulated.
Histidine is used by many proteins as a regulatory mechanism, changing the conformation and behavior of the polypeptide in acid regions such as the late endosome or lysosome.
Histidine is needed for growth and for repair of human tissues and is converted to a substance that stimulates the secretion of hydrochloric acid in the stomach to facilitate gastric function.
Most of the histidine processed in the body is derived from the diet. Natural sources of histidine include beans, dairy products, eggs, fish, meat nuts, seeds, soy and whey.
Amino acid of Histidine
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